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��о��˹¡—��հ�֢��ģ�MSKCC��о��Ա��ٴ��о�Э��Ȼ��Ϸ��ժҪCT036��MSKCC��طο��ҽ��ͼ�Ƥ��Ŀ��Prasad S. Adusumilli��Medscapeҽѧ��Ž��ͣ�“��CAR Tϸ��ʵ��ĵ�һ��ɹ��”

Adusumilliָ��“��о�֤��CAR Tϸ��뿹PD1��ϸ��壩��ʹ�ã��Ч��ʵ��”��˵��ַ��ͨ��CAR Tϸ��ʵ��‘��’��߷�Ӧ��ת��Ϊ‘��’��߷�Ӧ��͸��ϸ��߼��㣬��ϸ��߷�Ӧ��ά��ϸ��Ϊ��ϸ��

Adusumilli��˵��“��ʵ��ʹ��CAR Tϸ��ƵĹؼ��Ƿ��ҵ��ʵĿ�ԭ��ΪĿ�ꡣ��Ƥ��Ƥϸ��еͱ��(��)��ĳ��ʵ��У��൱�ߵı����²��˴��ʽ��͡��ʴˣ�CAR Tϸ��ڹ��ϸ��ͬʱ��˺��ļ�Ƥϸ��²��Ӧ��”

��ָ��Ӧ��Ԥ��ٴ�ǰ��д��˲��٣��ٴ�Ӧ��ʱ��Ҫ�ǳ��

1.��ذ�֢��

��μ��ݶ��ߵ��City of Hope��֢��ĵ��ҽ��Michael Caligiuri��Medscapeҽѧ��ű�ʾ��”��CAR Tϸ��Ӧ��ʵ��ĳɹ��˵�ǿ��˰�֢��Ƶ��”��˵��ʵ��Ѫ��ս�ԣ��Ϊ��Щ��ϸ��΢��CAR Tϸ��ԣ�δ��Ƶ�ͻ�ƻ��ʶ��µ�Ŀ�꣬�µĴ��ͷ��Լ��CAR Tϸ��Ƶ��Ʋ�ͬ��

Caligiuri��Ϊ��“��ģʽ”�� (��CAR Tϸ��Ʒ��)��ö��һ��ģʽ��Ĵ��·��о��ܵ��·��Ļ��ƺ��ƣ��ɵ�һҩ��ƿ�ʼ��չ��ҩ��һͬʹ�õ��Ʒ��ʾ��ж��Ƶ��Ч�Ƿ��CAR Tϸ��֮��硣

��ŷ��ϣ�Adusumilliָ��Ŀǰ��е��ʹ��Ƽ��Ƽ�Ƥ��ķ��̫��Ч��Ч��־á��CAR Tϸ��ĳ��Ժͼ�Ƥ�ر��½��Ʒ�Ӧ��CAR Tϸ��ģ��߼��Ƽ��Эͬ��á�

2.��Ƶ��֮��

Adusumilli��˵��о��֮�� :

1. ��Ŷ��ڼ�Ƥ�ذ��CAR Tϸ��һ��ΪIcasM28z�İ�ȫ��ء�

casM28z��һ�ִٽ�ϸ��“��ɱ”��أ��֮��Ķ��ԣ��ͨ��ע��ҩ���ɱ��ڵ��CAR Tϸ��ž��Ĳ��Ӧ��

2. ȷ��CAR Tϸ��ֱ��ע��Ĥǻ�ڸ�Ϊ��Ч��

Adusumilli��˵��“��ǹ۲쵽��CAR Tϸ��ע��ѪҺʱ��ǻ��ڷβ�ͣ��4��5�죬Ȼ��Ե�Ũ�Ƚ��”��˵��“ͨ��ֱ��ע��Ĥǻ��CAR Tϸ��ƹ��β��з�ֳ��ϸ��”

3. ��ǽ�CAR Tϸ��Ƽ��

Adusumilli��۵�� “��ǵ�һ��С��ʹ��CAR Tϸ��ʱ��ע�⵽��»�е�‘��’��” ��˵��“Ȼ��ǿ��ͨ��߼��¼��Щϸ��Կ��”

��ԭ��Զ��Ĥ��Ƥ��̷��ת��Լ��ΰ��鰩��Ķ��Ĥ��Ӱ��˳��150,000��ߡ�Adusumilliָ��“��ַ��ɹ��ÿ�꽫��200��Ƥ�ع��ȱ��ʵ��ߣ��ܻ��ơ�”

3.�о�ϸ��

Adusumilli��Ŷ��õڶ��CD28ȫ��Ƥ��CAR Tϸ��Icaspase-9��ȫ��IcasM28z��21��ж��Ĥ��֮��ʿ��У�19��ж��Ĥ��Ƥ��һ��зΰ��һ��鰩��

�о��Ա��ݼ��Ƶ��ˮƽ��ߡ��Զϲ�/��ӷ��ϲ�ɨ�裨CT/PET��Ķ�ͼ��İ��Һ�͸�ˮ��Լ��ٴ��ȷ��е��/��ⶾ�ԡ�

��߽��ܵ��CAR Tϸ��ÿ��3×105 - 1×107��ϸ��ƣ��ͨ��Ĥ��ܻ��Է��ע��ǻ�ڡ�18��߽��˶��⻯�ƣ��12��Խ��Է��CAR Tϸ��ơ�

CAR Tϸ��13��г��ش��ڣ��ӵ�2�쵽��42�ܣ��Ʒ�Ӧ��Ѫ��SMRP��Լ�Ƥ��ģ�ˮƽ��ͣ��Լ��ӳ��ɨ��п��С��

��ȷ��û��CAR Tϸ��ض��Ե��󣨼�û��񾭶��ԡ�û��ϸ��ͷ��ۺ�֢��û�ае��/��ⶾ�ԣ��߽��˼��Ƽ��PD1��壩��ƣ�CAR Tϸ��ע��6-17�ܲ��ȣ��Ʋ��ԭ��о��ƻ��ڣ��

�о��֣�15��ڷ��о��ڼ��˿�PD1��ƣ�1-21��ڲ��ȣ��û�в��Ӧ��ѵ��Ʒ�Ӧ��19��Ĥ��Ƥ��п��13��˿�PD1��Ʒ��PETɨ��ߵİ�֢��ȫ��ˣ��⣩��ֱ��ĿǰΪֹ��һ��ߵ��ȫ��״̬�ѽ��60�ܣ��һ��32�ܡ��⣬6��ߴﵽ��ֻ��⣬��4��߲��ȶ��

��11��ܻ��CAR Tϸ��3�ο�PD1��ƣ��Ҵﵽ��3��õĻ��У��Ʒ�Ӧ��Ϊ72��

��Ƥ�ذ��CAR Tϸ��Ƶ��һ��ʲô��

��һ��о��CAR Tϸ��ƵĹ�Ч��⣬Adusumilli��Ŷӽ��ʳƷ��ҩ��ֵ��׼��ڵ�3�ܸ��߼��Ƽ��ơ�

�Ŷӻ��о��CAR Tϸ��“�ն��”��һ��PD1�ĸ��壩��˵��“��ַ��С��Ч��ܺã��һ��źŴ��ɷݵĿ�PD1��ԡ��ַ��Ҫ��߼��Ƽ��ơ�”

MSKCC��Atara Biotherapeutics��Ȩע��ڼ�Ƥ��CAR��壬��ȡע��ѣ��ɸ��ע��ð�Ȩ�ѡ�Adusumilli��Sadelain��Ƶķ��ߣ��Խ��ע��һ��֣��ǵ�ʵ��Ŷӻ��Atara Biotherapeutics��о��ѡ�Caligiuri��CytoSense Therapeutics��Cellular Biomedicine Group�Ĺ��ίԱ��Ա��